Women’s Super League (WSL) will see Manchester United Women playing for the first time at Old Trafford when they host West Ham United.
Casey Stoney’s side, who usually play their home games at Leigh Sports Village, are due to host West Ham on March 27.
“Playing at Old Trafford will obviously be a special moment in the history of this team,” Stoney said in a statement.
“It’s a fantastic opportunity to showcase the women’s game, which has seen huge growth over the last few years.”
Spurs Women also host local rivals Arsenal at the Tottenham Hotspur Stadium, instead of The Hive where they usually play home matches, on the same day.
A league record crowd of 38,262 watched the WSL’s first north London derby in November 2019 at the stadium.